Siren, L.L.C.
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$3.61B
Q ending 2026-03-31
Prior quarter
$3.35B
Q ending 2025-12-31
Change
+7.6% QoQ · +103.5% YoY
Positions
100
reported holdings
Largest positions
All 100 reported positions, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Scholar Rock Holding Corp | SRRK | Shares | $532.2M | 10.8M |
| Kymera Therapeutics Inc | KYMR | Shares | $265.4M | 3.2M |
| Erasca Inc | ERAS | Shares | $181.9M | 11.2M |
| Edgewise Therapeutics Inc | EWTX | Shares | $139.6M | 4.4M |
| Beone Medicines Ag | ONC | Shares | $138.1M | 465K |
| Tango Therapeutics Inc | TNGX | Shares | $118.3M | 5.7M |
| Bicara Therapeutics Inc | BCAX | Shares | $115.4M | 5.8M |
| Revolution Medicines Inc | RVMD | Shares | $108.0M | 1.1M |
| Arrowhead Pharmaceuticals Inc | ARWR | Shares | $101.3M | 1.6M |
| Veradermics Inc | MANE | Shares | $95.1M | 1.5M |
| Xenon Pharmaceuticals Inc | XENE | Shares | $76.7M | 1.3M |
| Olema Pharmaceuticals Inc | OLMA | Shares | $70.9M | 4.8M |
| Crinetics Pharmaceuticals Inc | CRNX | Shares | $69.1M | 1.9M |
| Lexicon Pharmaceuticals Inc | LXRX | Shares | $69.1M | 44.3M |
| Cogent Biosciences Inc | COGT | Shares | $65.8M | 1.7M |
| Stoke Therapeutics Inc | STOK | Shares | $65.0M | 2.0M |
| Arcus Biosciences Inc | RCUS | Shares | $65.0M | 3.0M |
| Structure Therapeutics Inc | GPCR | Shares | $64.0M | 1.3M |
| Disc Medicine Inc | IRON | Shares | $63.2M | 988K |
| Rhythm Pharmaceuticals Inc | RYTM | Shares | $63.1M | 726K |
| Solid Biosciences Inc | SLDB | Shares | $55.4M | 7.7M |
| Septerna Inc | SEPN | Shares | $48.1M | 2.0M |
| Centessa Pharmaceuticals Plc | 260 | Shares | $41.8M | 1.1M |
| Spyre Therapeutics Inc | SYRE | Shares | $41.3M | 819K |
| Cytokinetics Inc | CYTK | Shares | $40.5M | 614K |
| Dyne Therapeutics, Inc | DYN | Shares | $40.4M | 2.2M |
| Taysha Gene Therapies Inc | TSHA | Shares | $39.5M | 8.8M |
| Dbv Technologies Sa | DBVT | Shares | $38.8M | 1.9M |
| Oric Pharmaceuticals Inc | ORIC | Shares | $38.0M | 3.0M |
| Engene Holdings Inc | Shares | $35.8M | 5.3M | |
| Palvella Therapeutics Inc | PVLA | Shares | $32.1M | 257K |
| Taboola.Com Ltd | Shares | $30.9M | 10.0M | |
| Enliven Therapeutics Inc | ELVN | Shares | $29.3M | 746K |
| Denali Therapeutics Inc | DNLI | Shares | $26.8M | 1.4M |
| Remitly Global Inc | RELY | Shares | $24.2M | 1.5M |
| Damora Therapeutics Inc | DMRA | Shares | $23.3M | 900K |
| Zura Bio Ltd | Shares | $22.2M | 3.7M | |
| Annexon Inc | ANNX | Shares | $21.9M | 4.0M |
| Trevi Therapeutics Inc | TRVI | Shares | $21.3M | 1.8M |
| Rapport Therapeutics Inc | RAPP | Shares | $20.1M | 641K |
| Alphabet Inc | GOOGL | Shares | $18.9M | 66K |
| Fulcrum Therapeutics Inc | FULC | Shares | $18.0M | 2.4M |
| Wave Life Sciences Ltd | Shares | $17.8M | 2.5M | |
| Definium Therapeutics Inc | DFTX | Shares | $17.4M | 919K |
| Amylyx Pharmaceuticals Inc | AMLX | Shares | $17.1M | 1.2M |
| Cullinan Therapeutics Inc | CGEM | Shares | $17.0M | 1.2M |
| Neumora Therapeutics Inc | NMRA | Shares | $16.6M | 8.5M |
| Uniqure Nv | Shares | $16.4M | 1.0M | |
| Cytomx Therapeutics Inc | CTMX | Shares | $16.3M | 3.5M |
| Nvidia Corp | NVDA | Shares | $15.5M | 89K |
| Silence Therapeutics Plc | SLN | Shares | $15.3M | 2.9M |
| Microsoft Corp | MSFT | Shares | $15.3M | 41K |
| Monopar Therapeutics Inc | MNPR | Shares | $14.8M | 270K |
| Taiwan Semiconductor Manufacturing | TSM | Shares | $14.3M | 42K |
| Sionna Therapeutics Inc | SION | Shares | $12.0M | 300K |
| Nebius Group Nv | Shares | $11.8M | 114K | |
| Rezolute Inc | RZLT | Shares | $10.2M | 3.3M |
| Inhibikase Therapeutics Inc | IKT | Shares | $9.8M | 5.8M |
| Amazon.Com Inc | AMZN | Shares | $9.7M | 47K |
| Generate Biomedicines Inc | GENB | Shares | $9.2M | 736K |
| Maplight Therapeutics Inc | MPLT | Shares | $9.1M | 450K |
| Servicenow Inc | NOW | Shares | $9.1M | 87K |
| Crowdstrike Holdings Inc | CRWD | Shares | $9.0M | 23K |
| Pdd Holdings Inc | PDD | Shares | $8.5M | 83K |
| Tesla Inc | TSLA | Shares | $8.0M | 22K |
| Novabridge Biosciences | NBP | Shares | $7.4M | 3.0M |
| Bicycle Therapeutics Plc | BCYC | Shares | $7.2M | 1.6M |
| Whitehawk Therapeutics Inc | WHWK | Shares | $7.2M | 2.1M |
| Tenax Therapeutics Inc | TENX | Shares | $6.8M | 427K |
| Vtv Therapeutics Inc | VTVT | Shares | $6.5M | 163K |
| Datadog Inc | DDOG | Shares | $6.4M | 54K |
| Jfrog Ltd | Shares | $6.0M | 129K | |
| Dynatrace Inc | DT | Shares | $5.5M | 150K |
| Workiva Inc | WK | Shares | $5.5M | 93K |
| Absci Corp | ABSI | Shares | $5.4M | 1.8M |
| Invivyd Inc | IVVD | Shares | $5.2M | 4.0M |
| Satellos Bioscience Inc | MSLE | Shares | $5.0M | 892K |
| Ionq Inc | IONQ | Shares | $4.9M | 170K |
| Broadcom Inc | AVGO | Shares | $4.6M | 15K |
| Agomab Therapeutics Nv | AGMB | Shares | $4.3M | 411K |
| Cellebrite Di Ltd | Shares | $4.3M | 312K | |
| Seer Inc | SEER | Shares | $4.1M | 2.5M |
| Korro Bio Inc | KRRO | Shares | $3.9M | 348K |
| Agenus Inc | AGEN | Shares | $3.6M | 1.1M |
| Foghorn Therapeutics Inc | FHTX | Shares | $3.4M | 721K |
| Forgent Power Solutions, Inc | FPS | Shares | $2.9M | 100K |
| Kalaris Therapeutics Inc | KLRS | Shares | $2.5M | 436K |
| Gitlab Inc | GTLB | Shares | $2.2M | 100K |
| Micron Technology Inc | MU | Shares | $2.0M | 6K |
| Monday.Com Ltd | Shares | $1.7M | 25K | |
| Gossamer Bio Inc | GOSS | Shares | $1.7M | 5.2M |
| Amer Sports Inc | Shares | $1.6M | 50K | |
| Ke Holdings Inc | BEKE | Shares | $1.5M | 100K |
| Iren Ltd | Shares | $1.5M | 43K | |
| Rani Therapeutics Holdings Inc | RANI | Shares | $1.5M | 2.0M |
| Aeva Technologies Inc | AEVA | Shares | $1.4M | 110K |
| Medline Inc | MDLN | Shares | $1.1M | 25K |
| Figma Inc | FIG | Shares | $1.1M | 50K |
| Primo Brands Corp | PRMB | Shares | $942K | 50K |
| Nu Holdings Ltd. | Shares | $359K | 25K |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.