Sphera Funds Management Ltd.
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$629.7M
Q ending 2026-03-31
Prior quarter
$517.3M
Q ending 2025-12-31
Change
+21.7% QoQ · +45.0% YoY
Positions
96
reported holdings
Largest positions
All 96 reported positions, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Mineralys Therapeutics Inc | MLYS | Shares | $36.3M | 1.3M |
| Teva Pharmaceutical Inds Ltd | TEVA | Shares | $34.2M | 1.1M |
| Tower Semiconductor Ltd | Shares | $25.6M | 146K | |
| Spdr Series Trust | XBI | Put | $25.5M | 200K |
| Nova Ltd | Shares | $23.2M | 53K | |
| Bridgebio Pharma Inc | BBIO | Shares | $18.2M | 245K |
| Cytokinetics Inc | CYTK | Call | $17.1M | 259K |
| Biogen Inc | BIIB | Shares | $17.0M | 93K |
| Ultragenyx Pharmaceutical In | RARE | Shares | $17.0M | 809K |
| Syndax Pharmaceuticals Inc | SNDX | Shares | $16.9M | 725K |
| Cogent Biosciences Inc | COGT | Shares | $16.0M | 416K |
| Sanofi Sa | SNY | Shares | $13.0M | 270K |
| Astrazeneca Plc | Shares | $12.3M | 63K | |
| Amicus Therapeutic | AM6 | Shares | $8.7M | 603K |
| Cellebrite Di Ltd | Shares | $8.7M | 632K | |
| Apellis Pharmaceuticals Inc | APLS | Shares | $8.6M | 215K |
| Palo Alto Networks Inc | PANW | Shares | $8.5M | 53K |
| Eli Lilly & Co | LLY | Shares | $8.3M | 9K |
| Biocryst Pharmaceuticals Inc | BCRX | Shares | $8.2M | 866K |
| Camtek Ltd | Shares | $8.0M | 53K | |
| Biomarin Pharmaceutical Inc | BMRN | Shares | $7.9M | 140K |
| Celldex Therapeutics Inc New | CLDX | Shares | $7.7M | 244K |
| Ormat Technologies Inc | ORA | Shares | $7.6M | 68K |
| Xenon Pharmaceuticals Inc | XENE | Shares | $7.4M | 127K |
| Soleno Therapeutics Inc | SLNOEUR | Shares | $7.2M | 216K |
| Tango Therapeutics Inc | TNGX | Shares | $7.2M | 344K |
| Johnson & Johnson | JNJ | Shares | $7.0M | 29K |
| Solaredge Technologies Inc | SEDG 2.25 07/01/29 | Shares | $6.9M | 4.0M |
| Immatics N.V | Shares | $6.8M | 696K | |
| Trevi Therapeutics Inc | TRVI | Shares | $6.8M | 574K |
| Oric Pharmaceuticals Inc | ORIC | Shares | $6.8M | 538K |
| Maze Therapeutics Inc | MAZE | Shares | $6.8M | 227K |
| Gsk Plc | GSK | Shares | $6.7M | 122K |
| Amazon Com Inc | AMZN | Shares | $6.7M | 32K |
| Abbvie Inc | ABBV | Shares | $6.6M | 30K |
| Applied Optoelectronics Inc | AAOI | Shares | $6.2M | 73K |
| Enliven Therapeutics Inc | ELVN | Shares | $6.0M | 153K |
| Merck & Co Inc | MRK | Shares | $5.8M | 49K |
| Vor Biopharma Inc | VOR | Shares | $5.7M | 322K |
| Acadia Pharmaceuticals Inc | ACAD | Shares | $5.7M | 256K |
| Novartis Ag | NVS | Shares | $5.7M | 37K |
| Eledon Pharmaceuticals Inc | ELDN | Shares | $5.5M | 1.8M |
| Enphase Energy Inc | ENPH | Shares | $5.4M | 142K |
| Revolution Medicines Inc | RVMD | Shares | $5.4M | 55K |
| Pfizer Inc | PFE | Shares | $5.2M | 186K |
| Biohaven Ltd | Shares | $5.0M | 594K | |
| Forte Biosciences Inc | FBRX | Shares | $4.8M | 185K |
| Cybin Inc | HELP | Shares | $4.7M | 987K |
| Madrigal Pharmaceuticals Inc | MDGL | Shares | $4.7M | 9K |
| Scholar Rock Hldg Corp | SRRK | Shares | $4.6M | 94K |
| Novo-Nordisk A S | NVO | Shares | $4.4M | 121K |
| Mediwound Ltd | Shares | $4.4M | 273K | |
| Kodiak Sciences Inc | KOD | Shares | $4.4M | 115K |
| Zenas Biopharma Inc | ZBIO | Shares | $4.2M | 214K |
| Promis Neurosciences Inc | PMN | Shares | $4.1M | 326K |
| Ishares Tr | TLT | Call | $4.1M | 47K |
| Relay Therapeutics Inc | RLAY | Shares | $4.1M | 408K |
| Savara Inc | SVRA | Shares | $4.0M | 739K |
| Wave Life Sciences Ltd | Shares | $4.0M | 548K | |
| Corvus Pharmaceuticals Inc | CRVS | Shares | $3.6M | 248K |
| Ovid Therapeutics Inc | OVID | Shares | $3.6M | 1.6M |
| Disc Medicine Inc | IRON | Shares | $3.4M | 54K |
| Upstream Bio Inc | UPB | Shares | $3.2M | 358K |
| Alpha Cognition Inc | ACOG | Shares | $3.1M | 568K |
| Palisade Bio Inc | PALI | Shares | $3.0M | 1.7M |
| Dyne Therapeutics Inc | DYN | Shares | $2.9M | 161K |
| Climb Bio Inc | CLYM | Shares | $2.9M | 419K |
| Zim Integrated Shipping Serv | Shares | $2.8M | 106K | |
| Satellos Bioscience Inc | MSLE | Shares | $2.8M | 489K |
| Solaredge Technologies Inc | SEDG | Shares | $2.7M | 53K |
| Amgen Inc | AMGN | Shares | $2.6M | 8K |
| Cytokinetics Inc | CYTK | Shares | $2.6M | 40K |
| Structure Therapeutics Inc | GPCR | Shares | $2.4M | 51K |
| Kura Oncology Inc | KURA | Shares | $2.4M | 296K |
| Generate Biomedicines Inc | GENB | Shares | $2.3M | 185K |
| Ishares Bitcoin Trust Etf | IBIT | Shares | $2.3M | 60K |
| Contineum Therapeutics Inc | CTNM | Shares | $2.3M | 173K |
| Tenax Therapeutics Inc | TENX | Shares | $2.2M | 136K |
| Prelude Therapeutics Inc | PRLD | Shares | $1.9M | 558K |
| Ascendis Pharma A/S | Shares | $1.8M | 8K | |
| Verastem Inc | VSTM | Shares | $1.8M | 344K |
| Voyager Therapeutics Inc | VYGR | Shares | $1.8M | 470K |
| Shattuck Labs Inc | STTK | Shares | $1.8M | 281K |
| Evommune Inc | EVMN | Shares | $1.8M | 78K |
| Bioage Labs Inc | BIOA | Shares | $1.5M | 87K |
| Olema Pharmaceuticals Inc | OLMA | Call | $1.5M | 100K |
| Organogenesis Hldgs Inc | ORGO | Shares | $1.3M | 550K |
| Curis Inc | CRISEUR | Shares | $1.1M | 2.0M |
| Bristol-Myers Squibb Co | BMY | Shares | $1.1M | 18K |
| Cytomx Therapeutics Inc. | CTMX | Shares | $1.0M | 220K |
| Nice Ltd | NICE | Shares | $619K | 6K |
| Werewolf Therapeutics Inc | HOWL | Shares | $522K | 627K |
| Skye Bioscience Inc | SKYE | Shares | $417K | 679K |
| Precision Biosciences Inc | DTIL | Shares | $220K | 40K |
| Aprea Therapeutics Inc | APRE | Shares | $206K | 270K |
| Foghorn Therapeutics Inc | FHTX | Shares | $58K | 12K |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.