Orbimed Advisors Llc
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$5.05B
Q ending 2026-03-31
Prior quarter
$4.90B
Q ending 2025-12-31
Change
+3.0% QoQ · +20.3% YoY
Positions
113
reported holdings
Largest positions
Top 100 of 113 reported positions by value, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Edgewise Therapeutics Inc | EWTX | Shares | $488.8M | 15.5M |
| Enliven Therapeutics Inc | ELVN | Shares | $312.0M | 8.0M |
| Mdxhealth Sa | Call | $285.9M | 124.3M | |
| Eli Lilly & Co | LLY | Shares | $217.8M | 237K |
| Sinovac Biotech Ltd | Shares | $184.5M | 2.7M | |
| Avita Medical Inc | RCEL | Call | $154.4M | 41.0M |
| Boston Scientific Corp | BSX | Shares | $149.5M | 2.4M |
| Sionna Therapeutics Inc | SION | Shares | $141.5M | 3.5M |
| Astrazeneca Plc | Shares | $132.2M | 670K | |
| Myriad Genetics Inc | MYGN | Principal | $122.9M | 125.0M |
| Mbx Biosciences Inc | MBX | Shares | $108.6M | 3.6M |
| Corvus Pharmaceuticals Inc | CRVS | Shares | $104.8M | 7.2M |
| Argenx Se | ARGX | Shares | $100.0M | 137K |
| Edwards Lifesciences Corp | EW | Shares | $98.5M | 1.2M |
| Intuitive Surgical Inc | ISRG | Shares | $96.2M | 209K |
| Compass Therapeutics Inc | CMPX | Shares | $80.5M | 15.2M |
| Merck & Co Inc | MRK | Shares | $79.8M | 663K |
| Structure Therapeutics Inc | GPCR | Shares | $71.1M | 1.5M |
| Arrivent Biopharma Inc | AVBP | Shares | $69.8M | 3.0M |
| Disc Medicine Inc | IRON | Shares | $68.3M | 1.1M |
| Ars Pharmaceuticals Inc | SPRY | Shares | $66.6M | 8.3M |
| Cg Oncology Inc | CGON | Shares | $64.2M | 948K |
| Xenon Pharmaceuticals Inc | XENE | Shares | $61.6M | 1.1M |
| Stryker Corporation | SYK | Shares | $60.0M | 183K |
| Bristol-Myers Squibb Co | BMY | Shares | $56.1M | 925K |
| Mineralys Therapeutics Inc | MLYS | Shares | $55.6M | 2.1M |
| Praxis Precision Medicines I | PRAX | Shares | $55.6M | 173K |
| Pfizer Inc | PFE | Shares | $54.7M | 1.9M |
| Dyne Therapeutics Inc | DYN | Shares | $52.9M | 2.9M |
| Natera Inc | NTRA | Shares | $52.4M | 262K |
| Abivax Sa | ABVX | Shares | $51.9M | 466K |
| Upstream Bio Inc | UPB | Shares | $51.2M | 5.7M |
| Danaher Corp Del | DHR | Shares | $50.4M | 266K |
| Caris Life Sciences Inc | CAI | Shares | $50.2M | 2.8M |
| Ascendis Pharma A/S | Shares | $41.6M | 182K | |
| Shattuck Labs Inc | STTK | Shares | $40.5M | 6.3M |
| Avita Medical Inc | RCEL | Principal | $40.5M | 40.5M |
| Guardant Health Inc | GH | Shares | $40.2M | 435K |
| Alnylam Pharmaceuticals Inc | ALNY | Shares | $39.4M | 119K |
| Prelude Therapeutics Inc | PRLD | Shares | $37.3M | 10.9M |
| Crinetics Pharmaceuticals In | CRNX | Shares | $36.3M | 999K |
| Axsome Therapeutics Inc. | AXSM | Shares | $36.2M | 214K |
| Uniqure Nv | Shares | $34.9M | 2.1M | |
| Oric Pharmaceuticals Inc | ORIC | Shares | $34.1M | 2.7M |
| Elevance Health Inc Formerly | ELV | Shares | $33.6M | 115K |
| Relmada Therapeutics Inc | RLMD | Shares | $32.8M | 4.7M |
| Forte Biosciences Inc | FBRX | Shares | $31.0M | 1.2M |
| Trevi Therapeutics Inc | TRVI | Shares | $29.3M | 2.5M |
| Esperion Therapeutics Inc Ne | Shares | $29.0M | 10.6M | |
| Neuropace Inc | NPCE | Shares | $27.6M | 2.1M |
| Rhythm Pharmaceuticals Inc | RYTM | Shares | $27.3M | 314K |
| Thermo Fisher Scientific Inc | TMO | Shares | $22.9M | 47K |
| Syndax Pharmaceuticals Inc | SNDX | Shares | $22.5M | 962K |
| Imagenebio Inc | Shares | $22.1M | 6.2M | |
| Brightspring Health Svcs Inc | BTSG | Shares | $21.2M | 498K |
| Lexeo Therapeutics Inc | LXEO | Shares | $20.7M | 3.6M |
| Sutro Biopharma Inc | STRO | Shares | $20.0M | 801K |
| Nektar Therapeutics | NKTR | Shares | $19.8M | 275K |
| Cybin Inc | HELP | Shares | $18.4M | 3.8M |
| Krystal Biotech Inc | KRYS | Shares | $17.8M | 69K |
| Palvella Therapeutics Inc Ne | PVLA | Shares | $16.8M | 135K |
| Corbus Pharmaceuticals Hldgs | CRBP | Shares | $16.3M | 1.7M |
| Urogen Pharma Ltd | Shares | $15.7M | 875K | |
| Definium Therapeutics Inc | DFTX | Shares | $15.2M | 804K |
| Vera Therapeutics Inc | VERA | Shares | $14.9M | 370K |
| Q32 Bio Inc | QTTB | Shares | $14.5M | 2.3M |
| Whitehawk Therapeutics Inc | WHWK | Shares | $14.4M | 4.2M |
| Amgen Inc | AMGN | Shares | $14.0M | 40K |
| Alignment Healthcare Inc | ALHC | Shares | $13.9M | 791K |
| Eyepoint Inc | EYPT | Shares | $13.8M | 1.1M |
| Janux Therapeutics Inc | JANX | Shares | $13.7M | 984K |
| Biocryst Pharmaceuticals Inc | BCRX | Shares | $13.6M | 1.4M |
| Bicara Therapeutics Inc | BCAX | Shares | $13.3M | 667K |
| Bioage Labs Inc | BIOA | Shares | $12.4M | 712K |
| Cogent Biosciences Inc | COGT | Shares | $12.4M | 322K |
| Alumis Inc | ALMS | Shares | $12.1M | 548K |
| Regeneron Pharmaceuticals | REGN | Shares | $11.4M | 15K |
| Carlsmed Inc | CARL | Shares | $11.3M | 1.3M |
| Biogen Inc | BIIB | Shares | $11.3M | 62K |
| Qiagen Nv | Call | $10.0M | 250K | |
| Kiniksa Pharmaceuticals Intl | Shares | $8.7M | 181K | |
| Keros Therapeutics Inc | KROS | Shares | $8.4M | 759K |
| Gilead Sciences Inc | GILD | Shares | $8.3M | 60K |
| Heron Therapeutics Inc | HRTX | Shares | $7.9M | 9.8M |
| Avalo Therapeutics Inc | AVTX | Shares | $7.1M | 475K |
| Tectonic Therapeutic Inc | TECX | Shares | $7.0M | 227K |
| Adicet Bio Inc | ACET | Shares | $7.0M | 1.0M |
| Compass Pathways Plc | CMPS | Shares | $6.4M | 1.2M |
| Palvella Therapeutics Inc Ne | PVLA | Call | $6.2M | 50K |
| Pharvaris N V | Shares | $5.8M | 205K | |
| Alx Oncology Hldgs Inc | ALXO | Shares | $5.7M | 2.9M |
| Artivion Inc | AORT | Shares | $5.5M | 151K |
| Inspiremd Inc | NSPR | Shares | $5.1M | 3.1M |
| Revolution Medicines Inc | RVMD | Shares | $5.1M | 52K |
| Adc Therapeutics Sa | Shares | $4.9M | 1.3M | |
| Protagonist Therapeutics Inc | PTGX | Shares | $4.4M | 42K |
| Palisade Bio Inc | PALI | Shares | $4.1M | 2.3M |
| Alto Neuroscience Inc | ANRO | Shares | $3.8M | 168K |
| Savara Inc | SVRA | Shares | $3.5M | 635K |
| Cullinan Therapeutics Inc | CGEM | Shares | $3.5M | 243K |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.