Stonepine Capital Management, Llc
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$249.7M
Q ending 2026-03-31
Prior quarter
$137.0M
Q ending 2025-12-31
Change
+82.3% QoQ · +143.0% YoY
Positions
83
reported holdings
Largest positions
All 83 reported positions, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Spdr Series Trust | XBI | Put | $51.1M | 400K |
| Spdr Series Trust | XBI | Call | $51.1M | 400K |
| Verastem Inc | VSTM | Shares | $17.5M | 3.3M |
| Tenax Therapeutics Inc | TENX | Shares | $15.6M | 975K |
| Adma Biologics Inc | ADMA | Call | $10.4M | 1.1M |
| Evolus Inc | EOLS | Shares | $7.2M | 1.8M |
| Adma Biologics Inc | ADMA | Shares | $6.7M | 740K |
| Camp4 Therapeutics Corp | CAMP | Shares | $6.1M | 1.4M |
| Nektar Therapeutics | NKTR | Shares | $6.1M | 85K |
| Terns Pharmaceuticals Inc | 430 | Call | $5.3M | 100K |
| Zevra Therapeutics Inc | ZVRA | Shares | $4.5M | 480K |
| Corbus Pharmaceuticals Hldgs | CRBP | Shares | $3.6M | 383K |
| Abeona Therapeutics Inc | ABEO | Shares | $3.3M | 747K |
| Establishment Labs Hldgs Inc | Call | $2.8M | 50K | |
| Kazia Therapeutics Ltd | KZIA | Shares | $2.6M | 345K |
| An2 Therapeutics Inc | ANTX | Shares | $2.4M | 714K |
| Alexandria Real Estate Eq In | ARE | Call | $2.3M | 50K |
| Acadia Pharmaceuticals Inc | ACAD | Call | $2.2M | 100K |
| Sol-Gel Technologies Ltd | Shares | $2.2M | 28K | |
| Xoma Royalty Corporation | X0M1 | Shares | $2.2M | 70K |
| Aytu Biopharma Inc | AYTU | Shares | $2.2M | 792K |
| Curis Inc | CRISEUR | Shares | $2.0M | 3.7M |
| Evolus Inc | EOLS | Call | $1.7M | 420K |
| Xeris Biopharma Holdings Inc | XERS | Call | $1.6M | 280K |
| Tela Bio Inc | TELA | Shares | $1.6M | 2.6M |
| Inhibikase Therapeutics Inc | IKT | Shares | $1.6M | 957K |
| Crescent Biopharma Inc. | Shares | $1.6M | 85K | |
| Adicet Bio Inc | ACET | Shares | $1.5M | 222K |
| X4 Pharmaceuticals Inc | XFOR | Shares | $1.4M | 335K |
| Okyo Pharma Ltd | Shares | $1.4M | 850K | |
| Si Bone Inc | SIBN | Call | $1.3M | 100K |
| Mannkind Corp | MNKD | Call | $1.2M | 500K |
| Heron Therapeutics Inc | HRTX | Shares | $1.1M | 1.4M |
| Pulmonx Corp | LUNG | Shares | $991K | 768K |
| In8Bio Inc | INAB | Shares | $982K | 663K |
| Neumora Therapeutics Inc. | NMRA | Call | $975K | 500K |
| Surrozen Inc | SRZN | Shares | $961K | 33K |
| Cytomx Therapeutics Inc. | CTMX | Call | $940K | 200K |
| Cytomx Therapeutics Inc. | CTMX | Shares | $940K | 200K |
| Delcath Sys Inc | DCTH | Call | $928K | 100K |
| Ardelyx Inc | ARDX | Call | $899K | 150K |
| Pmv Pharmaceuticals Inc | PMVP | Shares | $878K | 708K |
| Bioage Labs Inc | BIOA | Shares | $875K | 50K |
| Connect Biopharma Hldgs Ltd | Shares | $812K | 310K | |
| Heron Therapeutics Inc | HRTX | Call | $800K | 1.0M |
| Radiopharm Theranostics Ltd | RADX | Shares | $739K | 51.0M |
| Maxcyte Inc | MXCT | Shares | $706K | 1.0M |
| Codexis Inc | CDXS | Shares | $681K | 418K |
| Boundless Bio Inc | BOLD | Shares | $657K | 598K |
| Cybin Inc | HELP | Shares | $643K | 134K |
| Zentalis Pharmaceuticals Inc | ZNTL | Shares | $630K | 269K |
| Pasithea Therapeutics Corp | KTTA | Shares | $617K | 831K |
| Satellos Bioscience Inc | MSLE | Shares | $563K | 100K |
| Phathom Pharmaceuticals Inc | PHAT | Shares | $556K | 50K |
| Onkure Therapeutics Inc | OKUR | Shares | $549K | 133K |
| Xilio Therapeutics Inc | XLO | Shares | $540K | 64K |
| Verrica Pharmaceuticals Inc | VRCA | Shares | $528K | 100K |
| Candel Therapeutics Inc | CADL | Shares | $502K | 103K |
| Abeona Therapeutics Inc | ABEO | Call | $448K | 100K |
| Precision Optics Corp Inc Ma | POCI | Shares | $439K | 100K |
| Quoin Pharmaceuticals Ltd | QNRX | Shares | $353K | 53K |
| Establishment Labs Hldgs Inc | Shares | $341K | 6K | |
| Upstream Bio Inc | UPB | Shares | $315K | 35K |
| Opus Genetics Inc | IRD | Shares | $313K | 69K |
| Arvinas Inc | ARVN | Shares | $292K | 28K |
| Pliant Therapeutics Inc | PLRX | Shares | $283K | 225K |
| Janux Therapeutics Inc | JANX | Shares | $278K | 20K |
| Omniab Inc | OABI | Shares | $258K | 164K |
| Xeris Biopharma Holdings Inc | XERS | Shares | $232K | 40K |
| Compugen Ltd | Shares | $222K | 104K | |
| Neumora Therapeutics Inc. | NMRA | Shares | $195K | 100K |
| Sab Biotherapeutics Inc | SABS | Shares | $192K | 50K |
| Si Bone Inc | SIBN | Shares | $189K | 15K |
| Edesa Biotech Inc | EDSA | Shares | $157K | 30K |
| Cns Pharmaceuticals Inc | CNSP | Shares | $146K | 61K |
| Processa Pharmaceuticals Inc | PCSA | Shares | $139K | 55K |
| Cabaletta Bio Inc | CABA | Shares | $135K | 50K |
| Kalaris Therapeutics Inc | KLRS | Shares | $118K | 20K |
| Eledon Pharmaceuticals Inc | ELDN | Shares | $108K | 35K |
| Ovid Therapeutics Inc | OVID | Shares | $89K | 40K |
| Evaxion As | EVAX | Shares | $73K | 20K |
| Mannkind Corp | MNKD | Shares | $40K | 16K |
| Bioatla Inc | BCABGBP | Shares | $11K | 65K |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.