Paradigm Biocapital Advisors Lp
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$4.89B
Q ending 2026-03-31
Prior quarter
$3.92B
Q ending 2025-12-31
Change
+24.9% QoQ · +124.2% YoY
Positions
35
reported holdings
Largest positions
All 35 reported positions, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Arcellx Inc | ACLX | Shares | $663.0M | 5.8M |
| Revolution Medicines Inc | RVMD | Shares | $647.3M | 6.7M |
| Nuvalent Inc | 5AX | Shares | $545.5M | 5.3M |
| Vaxcyte Inc | PCVX | Shares | $278.5M | 4.8M |
| Edgewise Therapeutics Inc | EWTX | Shares | $232.0M | 7.4M |
| Genmab A/S | GMAB | Shares | $213.8M | 8.0M |
| Insmed Inc | INSM | Shares | $205.1M | 1.3M |
| Tarsus Pharmaceuticals Inc | TARS | Shares | $179.7M | 2.6M |
| Belite Bio Inc | BLTE | Shares | $177.7M | 1.1M |
| Erasca Inc | ERAS | Shares | $168.2M | 10.4M |
| Centessa Pharmaceuticals Plc | 260 | Shares | $142.0M | 3.6M |
| Olema Pharmaceuticals Inc | OLMA | Shares | $119.6M | 8.0M |
| Terns Pharmaceuticals Inc | 430 | Shares | $116.9M | 2.2M |
| Oruka Therapeutics Inc | ORKA | Shares | $113.8M | 2.3M |
| Apogee Therapeutics Inc | APGE | Shares | $113.5M | 1.3M |
| Spyre Therapeutics Inc | SYRE | Shares | $98.7M | 2.0M |
| Cytokinetics Inc | CYTK | Shares | $97.6M | 1.5M |
| Abivax Sa | ABVX | Shares | $86.0M | 772K |
| Tango Therapeutics Inc | TNGX | Shares | $83.9M | 4.0M |
| Maze Therapeutics Inc | MAZE | Shares | $81.9M | 2.7M |
| Tyra Biosciences Inc | TYRA | Shares | $78.7M | 2.1M |
| Viridian Therapeutics Inc | VRDN | Shares | $61.6M | 3.1M |
| Scholar Rock Hldg Corp | SRRK | Shares | $60.3M | 1.2M |
| Mirum Pharmaceuticals Inc | MIRM | Shares | $57.7M | 625K |
| Eyepoint Inc | EYPT | Shares | $40.5M | 3.1M |
| Lexeo Therapeutics Inc | LXEO | Shares | $35.5M | 6.2M |
| Veradermics Inc | MANE | Shares | $33.2M | 525K |
| Vor Biopharma Inc | VOR | Shares | $31.2M | 1.8M |
| Urogen Pharma Ltd | Shares | $30.6M | 1.7M | |
| Structure Therapeutics Inc | GPCR | Shares | $26.3M | 545K |
| Inventiva Sa | IVA | Shares | $22.2M | 4.0M |
| Oric Pharmaceuticals Inc | ORIC | Shares | $21.6M | 1.7M |
| Assembly Biosciences Inc | ASMB | Shares | $18.5M | 665K |
| Bridgebio Oncology Therapeut | BBOT | Shares | $7.8M | 868K |
| Kalaris Therapeutics Inc | KLRS | Shares | $4.0M | 700K |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.