Opaleye Management Inc.
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$759.2M
Q ending 2026-03-31
Prior quarter
$757.9M
Q ending 2025-12-31
Change
+0.2% QoQ · +69.0% YoY
Positions
54
reported holdings
Largest positions
All 54 reported positions, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Harrow Inc | HROW | Shares | $99.9M | 2.8M |
| Liquidia Corporation | LQDA | Shares | $88.8M | 2.5M |
| Eton Pharmaceuticals Inc | ETON | Shares | $70.6M | 2.9M |
| Sol-Gel Technologies Ltd | Shares | $39.6M | 500K | |
| Rhythm Pharmaceuticals Inc | RYTM | Shares | $35.3M | 123K |
| Apogee Therapeutics Inc | APGE | Shares | $32.8M | 390K |
| Disc Medicine Inc | IRON | Shares | $26.9M | 421K |
| Urogen Pharma Ltd | Shares | $25.7M | 1.4M | |
| Crescent Biopharma Inc. | Shares | $24.1M | 1.3M | |
| Stoke Therapeutics Inc | STOK | Shares | $22.8M | 700K |
| Perspective Therapeutics Inc | CATX | Shares | $19.5M | 4.7M |
| Rezolute Inc | RZLT | Shares | $19.2M | 6.3M |
| Meiragtx Hldgs Plc | Shares | $18.4M | 2.1M | |
| Tg Therapeutics Inc | TGTX | Shares | $17.8M | 535K |
| Sanuwave Health Inc | SNWV | Shares | $17.0M | 981K |
| Edgewise Therapeutics Inc | EWTX | Shares | $15.8M | 500K |
| Alpha Cognition Inc | ACOG | Shares | $14.1M | 2.6M |
| Annexon Inc | ANNX | Shares | $12.9M | 2.3M |
| Alumis Inc | ALMS | Shares | $12.1M | 550K |
| Codexis Inc | CDXS | Shares | $11.1M | 6.8M |
| Protagonist Therapeutics Inc | PTGX | Shares | $10.5M | 100K |
| Revolution Medicines Inc | RVMD | Shares | $9.7M | 100K |
| Xoma Royalty Corporation | X0M1 | Shares | $9.4M | 300K |
| Q32 Bio Inc | QTTB | Shares | $8.1M | 1.3M |
| Mbx Biosciences Inc | MBX | Shares | $7.8M | 260K |
| Relmada Therapeutics Inc | RLMD | Shares | $6.5M | 935K |
| Cg Oncology Inc | CGON | Shares | $6.4M | 95K |
| Jade Biosciences Inc | JBIO | Shares | $6.0M | 428K |
| Ocular Therapeutix Inc | OCUL | Shares | $5.1M | 600K |
| Assertio Holdings Inc | AH30 | Shares | $5.1M | 266K |
| Editas Medicine Inc | EDIT | Shares | $4.8M | 1.9M |
| Sutro Biopharma Inc | STRO | Shares | $4.7M | 191K |
| Journey Med Corp | DERM | Shares | $4.5M | 960K |
| Voyager Therapeutics Inc | VYGR | Shares | $4.4M | 1.1M |
| Trevi Therapeutics Inc | TRVI | Shares | $4.1M | 345K |
| Tectonic Therapeutic Inc | TECX | Shares | $3.8M | 123K |
| Cabaletta Bio Inc | CABA | Shares | $3.7M | 1.4M |
| Biodesix Inc | BDSX | Shares | $3.5M | 238K |
| Rocket Pharmaceuticals Inc | RCKT | Shares | $3.4M | 955K |
| Zentalis Pharmaceuticals Inc | ZNTL | Shares | $3.3M | 1.4M |
| Intellia Therapeutics Inc | NTLA | Shares | $3.1M | 245K |
| Fortress Biotech Inc | FBIO | Shares | $2.9M | 1.0M |
| Opus Genetics Inc | IRD | Shares | $2.3M | 1.1M |
| Rigel Pharmaceuticals Inc | RIGL | Shares | $1.9M | 70K |
| Atea Pharmaceuticals Inc | AVIR | Shares | $1.7M | 323K |
| Lyell Immunopharma Inc | LYEL | Shares | $1.6M | 79K |
| Enanta Pharmaceuticals Inc | ENTA | Shares | $1.6M | 125K |
| Nextcure Inc | NXTC | Shares | $1.5M | 141K |
| 4D Molecular Therapeutics In | FDMT | Shares | $1.0M | 112K |
| Perspective Therapeutics Inc | Shares | $834K | 200K | |
| Protalix Biotherapeutics Inc | PLX | Shares | $738K | 340K |
| Bridgebio Oncology Therapeut | BBOT | Shares | $477K | 53K |
| Lb Pharmaceuticals Inc | LBRX | Shares | $358K | 15K |
| Adagio Med Hldgs Inc | ADGM | Shares | $21K | 18K |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.