Deerfield Management Company, L.P.
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$8.48B
Q ending 2026-03-31
Prior quarter
$7.83B
Q ending 2025-12-31
Change
+8.3% QoQ · +67.4% YoY
Positions
82
reported holdings
Largest positions
All 82 reported positions, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Nuvalent Inc | 5AX | Shares | $1.77B | 17.2M |
| Brookdale Sr Living Inc | BKD 3.5 10/15/29 | Principal | $505.4M | 306.9M |
| Cogent Biosciences Inc | COGT | Shares | $348.1M | 9.0M |
| Praxis Precision Medicines I | PRAX | Shares | $310.4M | 963K |
| Viatris Inc | VTRS | Shares | $273.0M | 20.2M |
| United Therapeutics Corp Del | UTHR | Shares | $271.0M | 457K |
| Revolution Medicines Inc | RVMD | Shares | $223.4M | 2.3M |
| Mirum Pharmaceuticals Inc | MIRM 4 05/01/29 | Principal | $209.4M | 70.0M |
| Arrowhead Pharmaceuticals In | ARWR 0 01/15/32 | Principal | $207.2M | 200.0M |
| Celcuity Inc | CELC | Shares | $195.6M | 1.7M |
| Centene Corp Del | CNC | Shares | $193.7M | 5.9M |
| Larimar Therapeutics Inc | LRMR | Shares | $160.2M | 35.6M |
| Brookdale Sr Living Inc | BKD | Shares | $159.2M | 11.6M |
| Vera Therapeutics Inc | VERA | Shares | $149.7M | 3.7M |
| Ionis Pharmaceuticals Inc | IONS | Shares | $148.7M | 2.0M |
| Biocryst Pharmaceuticals Inc | BCRX | Shares | $143.2M | 15.0M |
| Inspire Med Sys Inc | INSP | Shares | $139.4M | 2.7M |
| Legend Biotech Corp | LEGN | Shares | $139.1M | 7.7M |
| Adapthealth Corp | AHCO | Shares | $136.6M | 11.5M |
| Newamsterdam Pharma Company | Shares | $136.5M | 4.3M | |
| Acadia Healthcare Company In | ACHC | Shares | $105.7M | 4.5M |
| Arrowhead Pharmaceuticals In | ARWR | Shares | $98.6M | 1.6M |
| Catalyst Pharmaceuticals Inc | Shares | $97.6M | 3.9M | |
| Indivior Pharmaceuticals Inc | INDV | Shares | $94.4M | 3.1M |
| Xenon Pharmaceuticals Inc | XENE | Shares | $94.0M | 1.6M |
| Ionis Pharmaceuticals Inc | IONS 1.75 06/15/28 | Principal | $90.6M | 60.0M |
| Pharvaris N V | Shares | $88.3M | 3.1M | |
| Syndax Pharmaceuticals Inc | SNDX | Shares | $88.3M | 3.8M |
| Tango Therapeutics Inc | TNGX | Shares | $86.8M | 4.1M |
| Alignment Healthcare Inc | ALHC 4.25 11/15/29 | Principal | $85.9M | 61.0M |
| Dianthus Therapeutics Inc | DNTH | Shares | $85.6M | 1.0M |
| Pfizer Inc | PFE | Shares | $85.4M | 3.0M |
| Neurocrine Biosciences Inc | NBIX | Shares | $80.4M | 610K |
| Day One Biopharmaceuticals I | DAWNGBX | Shares | $79.8M | 3.7M |
| Savara Inc | SVRA | Shares | $74.1M | 13.6M |
| Zenas Biopharma Inc | ZBIO 2.5 04/01/32 | Principal | $67.3M | 65.0M |
| Enhabit Inc | EHABUSD | Shares | $66.9M | 4.7M |
| Neogenomics Inc | NEO 0.25 01/15/28 | Principal | $66.7M | 72.7M |
| Genmab A/S | GMAB | Shares | $66.1M | 2.5M |
| Bio Rad Labs Inc | BIO | Shares | $63.0M | 226K |
| Lantheus Hldgs Inc | LNTH | Shares | $62.8M | 828K |
| Ars Pharmaceuticals Inc | SPRY | Shares | $60.3M | 7.5M |
| Stoke Therapeutics Inc | STOK | Shares | $59.4M | 1.8M |
| Envista Holdings Corporation | NVST | Shares | $56.1M | 2.2M |
| Ideaya Biosciences Inc | IDYA | Shares | $51.0M | 1.5M |
| Belite Bio Inc | BLTE | Shares | $48.5M | 304K |
| Biomarin Pharmaceutical Inc | BMRN | Shares | $48.1M | 852K |
| Kymera Therapeutics Inc | KYMR | Shares | $46.7M | 561K |
| Certara Inc | CERT | Shares | $44.5M | 7.8M |
| Bridgebio Oncology Therapeut | BBOT | Shares | $43.7M | 4.9M |
| Disc Medicine Inc | IRON | Shares | $42.0M | 657K |
| Livanova Plc | LIVN 2.5 03/15/29 | Principal | $40.0M | 34.3M |
| Sionna Therapeutics Inc | SION | Shares | $38.9M | 971K |
| Caredx Inc | CDNA | Shares | $38.0M | 2.2M |
| Structure Therapeutics Inc | GPCR | Shares | $37.0M | 768K |
| Immunocore Hldgs Plc | IMCR 2.5 02/01/30 | Principal | $27.0M | 30.0M |
| Veracyte Inc | VCYT | Shares | $23.4M | 726K |
| Alnylam Pharmaceuticals Inc | ALNY | Shares | $22.5M | 68K |
| Embecta Corp | EMBC | Shares | $22.4M | 2.5M |
| Tyra Biosciences Inc | TYRA | Shares | $21.0M | 549K |
| Foghorn Therapeutics Inc | FHTX | Shares | $21.0M | 4.4M |
| Bright Minds Biosciences Inc | DRUG | Shares | $20.7M | 283K |
| Compass Therapeutics Inc | CMPX | Shares | $19.1M | 3.6M |
| Monopar Therapeutics Inc | MNPR | Shares | $17.7M | 324K |
| Kyverna Therapeutics Inc | KYTX | Shares | $17.3M | 2.0M |
| Spyglass Pharma Inc | SGP | Shares | $14.3M | 550K |
| Beta Bionics Inc | BBNX | Shares | $13.3M | 1.3M |
| Taysha Gene Therapies Inc | TSHA | Shares | $12.2M | 2.7M |
| The Oncology Institute Inc | TOI | Shares | $10.3M | 3.4M |
| Cullinan Therapeutics Inc | CGEM | Shares | $5.5M | 386K |
| Annexon Inc | ANNX | Shares | $3.2M | 584K |
| Alector Inc | ALEC | Shares | $2.3M | 1.1M |
| Newamsterdam Pharma Company | Shares | $1.9M | 93K | |
| Edwards Lifesciences Corp | EW | Shares | $1.1M | 14K |
| Biomx Inc | PHGE | Shares | $493K | 131K |
| Veradermics Inc | MANE | Shares | $316K | 5K |
| Humana Inc | HUM | Shares | $159K | 917 |
| The Oncology Institute Inc | TOIIW | Shares | $55K | 1.3M |
| Quantum Si Inc | QSIAW | Shares | $36K | 333K |
| Pmv Pharmaceuticals Inc | PMVP | Shares | $11K | 9K |
| Surrozen Inc | SRZNW | Shares | $3K | 167K |
| Myriad Genetics Inc | MYGN | Shares | $2K | 505 |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.