Baker Bros. Advisors Lp
Institutional manager — quarterly 13F holdings, Q ending 2026-03-31
Reported value
$17.42B
Q ending 2026-03-31
Prior quarter
$17.08B
Q ending 2025-12-31
Change
+2.0% QoQ · +92.7% YoY
Positions
84
reported holdings
Largest positions
All 84 reported positions, Q ending 2026-03-31. A manager can hold shares, calls and puts on the same security at once — such positions are listed as separate rows. Type: Shares = common stock, Put/Call = option positions (valued at the underlying), Principal = debt. Tickers link to stock pages where covered.
| Holding | Ticker | Type | Value ▼ | Shares |
|---|---|---|---|---|
| Incyte Corporation | INCY | Shares | $2.89B | 30.7M |
| Beone Medicines Ltd. | ONC | Shares | $2.61B | 8.8M |
| Insmed Incorporated | INSM | Shares | $1.21B | 7.4M |
| Madrigal Pharmaceuticals, Inc. | MDGL | Shares | $1.12B | 2.1M |
| Acadia Pharmaceuticals Inc. | ACAD | Shares | $954.9M | 42.9M |
| Revolution Medicines, Inc. | RVMD | Shares | $929.3M | 9.6M |
| Celcuity Inc. | CELC | Shares | $903.5M | 7.9M |
| Kodiak Sciences Inc. | KOD | Shares | $759.3M | 19.9M |
| Kymera Therapeutics, Inc. | KYMR | Shares | $721.1M | 8.7M |
| Summit Therapeutics Inc. | SMMT | Shares | $690.0M | 36.4M |
| Praxis Precision Medicines, Inc. | PRAX | Shares | $564.9M | 1.8M |
| Rhythm Pharmaceuticals, Inc. | RYTM | Shares | $487.4M | 5.6M |
| Alkermes Plc | Shares | $354.0M | 10.0M | |
| Grail, Inc. | GRAL | Shares | $208.2M | 4.0M |
| Edgewise Therapeutics, Inc. | EWTX | Shares | $207.1M | 6.6M |
| Ionis Pharmaceuticals, Inc. | IONS | Shares | $153.8M | 2.0M |
| Kiniksa Pharmaceuticals Internatio | Shares | $136.1M | 2.8M | |
| Immunovant, Inc. | IMVT | Shares | $135.6M | 5.5M |
| Roivant Sciences Ltd. | Shares | $134.8M | 4.9M | |
| Ideaya Biosciences, Inc. | IDYA | Shares | $131.5M | 3.9M |
| Arrowhead Pharmaceuticals, Inc. | ARWR | Shares | $124.9M | 2.0M |
| Stoke Therapeutics, Inc. | STOK | Shares | $108.6M | 3.3M |
| Immatics N.V. | Shares | $107.4M | 10.9M | |
| Abcellera Biologics Inc. | ABCL | Shares | $105.7M | 30.3M |
| Abivax S.A. | ABVX | Shares | $97.5M | 876K |
| Crinetics Pharmaceuticals, Inc. | CRNX | Shares | $85.4M | 2.4M |
| Replimune Group, Inc. | REPL | Shares | $84.5M | 11.0M |
| Celcuity Inc. | CELC 2.75 08/01/31 | Shares | $74.9M | 30.8M |
| Nurix Therapeutics, Inc. | NRIX | Shares | $72.2M | 4.7M |
| Denali Therapeutics Inc. | DNLI | Shares | $71.6M | 3.7M |
| Dianthus Therapeutics, Inc. | DNTH | Shares | $71.5M | 852K |
| Monte Rosa Therapeutics, Inc. | GLUE | Shares | $71.5M | 4.3M |
| Structure Therapeutics Inc. | GPCR | Shares | $69.0M | 1.4M |
| Entrada Therapeutics, Inc. | TRDA | Shares | $64.0M | 5.1M |
| Bicycle Therapeutics Plc | BCYC | Shares | $50.5M | 10.9M |
| Spyre Therapeutics, Inc. | SYRE | Shares | $50.4M | 1.0M |
| Rapport Therapeutics, Inc. | RAPP | Shares | $48.4M | 1.5M |
| Alumis Inc. | ALMS | Shares | $44.3M | 2.0M |
| Mirum Pharmaceuticals, Inc. | MIRM | Shares | $41.2M | 446K |
| Viridian Therapeutics, Inc. | VRDN | Shares | $38.6M | 2.0M |
| Enliven Therapeutics, Inc. | ELVN | Shares | $35.5M | 905K |
| Prelude Therapeutics Inc. | PRLD | Shares | $34.6M | 10.1M |
| Dbv Technologies S.A. | DBVT | Shares | $30.5M | 1.5M |
| Design Therapeutics, Inc. | DSGN | Shares | $27.5M | 2.6M |
| Centessa Pharmaceuticals Plc | 260 | Shares | $26.6M | 671K |
| Cytomx Therapeutics, Inc. | CTMX | Shares | $23.4M | 5.0M |
| Jade Biosciences, Inc. | JBIO | Shares | $23.1M | 1.6M |
| Disc Medicine, Inc. | IRON | Shares | $22.4M | 350K |
| Immunocore Holdings Plc | IMCR | Shares | $22.1M | 734K |
| Xenon Pharmaceuticals Inc. | XENE | Shares | $21.5M | 370K |
| Celldex Therapeutics, Inc. | CLDX | Shares | $21.1M | 665K |
| Neurogene Inc. | NGNE | Shares | $20.0M | 992K |
| Evommune, Inc. | EVMN | Shares | $19.5M | 847K |
| Tectonic Therapeutic, Inc. | TECX | Shares | $18.8M | 608K |
| Contineum Therapeutics, Inc. | CTNM | Shares | $18.6M | 1.4M |
| Argenx Se | ARGX | Shares | $18.4M | 25K |
| Cerus Corporation | CERS | Shares | $18.2M | 10.0M |
| Taysha Gene Therapies, Inc. | TSHA | Shares | $17.9M | 4.0M |
| Aktis Oncology, Inc. | AKTS | Shares | $17.8M | 996K |
| Generate Biomedicines, Inc. | GENB | Shares | $17.8M | 1.4M |
| Sionna Therapeutics, Inc. | SION | Shares | $16.0M | 400K |
| Dyne Therapeutics, Inc. | DYN | Shares | $14.7M | 813K |
| Xencor, Inc. | XNCR | Shares | $13.3M | 1.1M |
| Compass Pathways Plc | CMPS | Shares | $13.0M | 2.3M |
| Relay Therapeutics, Inc. | RLAY | Shares | $11.5M | 1.2M |
| Sera Prognostics, Inc. | SERA | Shares | $11.2M | 5.5M |
| Biontech Se | BNTX | Shares | $10.6M | 120K |
| Pharvaris N.V. | Shares | $10.6M | 375K | |
| Arcus Biosciences, Inc. | RCUS | Shares | $9.0M | 416K |
| Maplight Therapeutics, Inc. | MPLT | Shares | $7.4M | 365K |
| Absci Corporation | ABSI | Shares | $6.4M | 2.1M |
| Wave Life Sciences Ltd. | Shares | $6.0M | 823K | |
| Vtv Therapeutics, Inc. | VTVT | Shares | $5.9M | 148K |
| Eikon Therapeutics, Inc. | EIKN | Shares | $5.9M | 556K |
| Protara Therapeutics, Inc. | TARA | Shares | $5.1M | 972K |
| Sagimet Biosciences Inc. | SGMT | Shares | $5.0M | 953K |
| Lb Pharmaceuticals Inc. | LBRX | Shares | $4.9M | 200K |
| Verastem, Inc. | VSTM | Shares | $3.1M | 585K |
| Tscan Therapeutics, Inc. | TCRX | Shares | $2.8M | 2.8M |
| Skye Bioscience, Inc. | SKYE | Shares | $968K | 1.6M |
| Sana Biotechnology, Inc. | SANA | Shares | $894K | 310K |
| Aligos Therapeutics, Inc. | ALGS | Shares | $617K | 83K |
| Tyra Biosciences, Inc. | TYRA | Shares | $406K | 11K |
| Surrozen, Inc. | SRZNW | Shares | $13K | 833K |
Values as reported in public regulatory filings (USD); holdings are reported quarterly, up to 45 days after quarter end, and may contain reporting errors. Nothing here is investment advice.